HLA-B27 Positive – What is HLA-B27?


HLA-B27 is a human leukocyte antigen found in human blood that is associated with some autoimmune disorders. The test is sometimes performed as part of an arthritis panel when patients exhibit specific arthritis symptoms. If it is present in the blood, it may indicate an inflammatory spondyloarthropathy such as anklylosing spondylitis.

The test is sometimes performed as part of an arthritis panel – image by pinterest.com

Testing for HLA-B27

HLA-B27 is a human leukocyte antigen that was discovered in 1972 to have association with ankylosing spondylitis. Since that time, it has been linked to over 100 inflammatory conditions that affect the eyes, skin, joints, and bowels.

HLA-B27 is a human leukocyte antigen – image by ihr.org.vn

Because HLA-B27 is a genetic marker for certain conditions and can be present in the blood without the presence of disease, tests are usually only performed if there is clinical suspicion of an associated disease. If HLA-B27 is present in a patient’s blood and correlates with patient symptoms, a diagnosis can be made.

HLA-B27 Spondyloarthropathies and Inflammatory Conditions

The spondyloarthropathies and other HLA-B27-related conditions are inflammatory in nature. This means that symptoms wax and wane in severity based on the amount of inflammation present.

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Conditions classified as Spondyloarthropathies – image by verywellhealth.com

Doctors may test for inflammation with blood tests like the ESR (Erythrocyte Sedimentation Rate) or CRP (C-Reactive Protein). High levels of inflammation (or small amounts over the long term) may cause permanent damage to joints and other tissues. The most common HLA-B27 spondyloarthropathies are:

  • Anklylosing Spondylitis
  • Reactive Arthritis
  • Psoriatic Arthritis
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Anklylosing Spondylitis – image by spineuniverse.com

These conditions may mimic other type of inflammatory arthritis such as rheumatoid arthritis. However, the spondyloarthropathies all have distinct signs and symptoms in addition to the presence of HLA-B27.

A rheumatologist, a physician who specializes in autoimmune diseases, is the best person to diagnose and treat such conditions. Even then, it is not always easy to determine the exact type of inflammatory arthritis.

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A rheumatologist is the best person to diagnose and treat such conditions – image by everydayhealth.com

Symptoms of Spondylarthropathies

The HLA-B27 spondyloarthropathies share certain observable characteristics, including symptoms to the spine, joints, tendons, eyes, and skin.

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image by verywellhealth.com

Ankylosing Spondylitis – (AS) affects the spine, large joints, and digits with morning stiffness and pain. During acute flare-ups, fever, anemia, and other constitutional symptoms may be present and it may also inflame the heart, lungs, or chest wall. Some AS patients experience uveitis, an inflammation of the eye, but it is not usually severe.

Some AS patients experience uveitis – image by creakyjoints.com

Back pain is the most common symptom with progressive kyphosis (hunching of the spine) and loss of flexibility.

Psoriatic Arthritis – Patients with psoriasis and HLA-B27 may develop psoriatic arthritis. This type of arthritis is usually asymmetric which means if one knee is affected, the other may not be. Rheumatoid Arthritis (RA), by contrast, is symmetric (both sides affected simultaneously).

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Psoriatic Arthritis – image by medscape.com

Psoriatic arthritis also affects the DIP joints of the fingers (the joints closest to the fingernails) which are rarely affected by RA. Since flares of psoriasis and arthritis can occur separately, psoriatic arthritis may not be suspected initially.

Reactive Arthritis – Just as it sounds reactive arthritis occurs in reaction to something else – an infection. It usually follows a urinary tract or gastrointestinal tract infection.

Reactive Arthritis Symptoms
Reactive Arthritis symptoms – image by drhardaayurveda.com

The arthritis varies in severity and may be combined with eye inflammation, mouth sores, and other skin lesions. Although, reactive arthritis initially resolves within three to four months, up to 50% of patients will have ongoing arthritis symptoms that wax and wane.

Juvenile Spondyloarthropathies and HLA-B27 Inflammatory Conditions

Some of the HLA-B27 spondyloarthropathies affect children. Children who manifest the appropriate symptoms under age 18 will be diagnosed with a juvenile spondyloarthropathy, but this is rare.

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juvenile spondyloarthropathy – image by nature.com

Most symptoms will not fully manifest until adulthood. This is why many children with HLA-B27 spondyloarthropathies will first be diagnosed as having Juvenile Rheumatoid Arthritis (JRA).

Two other inflammatory conditions associated with the HLA-B27 marker are Inflammatory Bowel Syndrome (IBS) and Acute Anterior Uveitis. Patients with these syndromes may also suffer from arthritis symptoms.

Inflammytory bowel disease – image by istockphoto.com

For all inflammatory arthropathies, controlling inflammation is the key to effective treatment. Long-term inflammation leads to damage of joints and other tissues. Patients may be treated with anti-inflammatory medications or even disease-modifying agents. Rheumatologists generally manage medications for patients with HLA-B27 conditions.


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